Curology vs Apostrophe: which is better?
Reviewed by the WeighedHealth Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of July 2026; updated when guidance or availability changes.
Curology and Apostrophe are the two largest custom-Rx skincare telehealth services, both targeting acne, anti-aging, and pigmentation. Apostrophe is exclusively staffed by board-certified dermatologists (not nurse practitioners or PAs) and ships full-strength Rx tubes individually rather than a compounded blend — meaning if one ingredient stops working, the others continue. Curology pioneered the compounded-blend approach, which simplifies routine (one bottle) but limits flexibility. Pricing: Curology $39.95/mo trial-included; Apostrophe $24.99-49.99 depending on which Rx are needed. For complex skin (perioral dermatitis, rosacea, severe acne), Apostrophe's board-certified-only model has the edge. For straightforward acne or anti-aging, Curology's compounded-blend is easier to use.
Related questions
How much does Curology cost?
Curology costs $39.95/month for the custom Rx formula bottle. Trial is free shipping-only ($4.95). Cleanser/moisturizer add-ons run $14-22 each. Cancel anytime free.