Orforglipron side effects
Orforglipron · orforglipron · by Eli Lilly
Reviewed by the WeighedHealth Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of July 2026; updated when guidance or availability changes.
GI side effects typical of the GLP-1 class: nausea, diarrhea, constipation, vomiting, especially during titration. Trial tolerability broadly comparable to injectable GLP-1s.
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People also ask
Frequently asked
What are the most common Orforglipron side effects?+
GI side effects typical of the GLP-1 class: nausea, diarrhea, constipation, vomiting, especially during titration. Trial tolerability broadly comparable to injectable GLP-1s.
How long do Orforglipron side effects last?+
Most GI side effects (nausea, constipation) peak in the first 4-8 weeks of dose escalation and improve as the body adapts. Severe or persistent symptoms warrant a clinician call.
When should I stop Orforglipron?+
Stop and contact a clinician for severe abdominal pain, persistent vomiting, signs of pancreatitis, gallbladder symptoms, or any reaction outside the expected GI profile.